Martínez AA, Conboy A, Buskirk SW, Marad DA, Lang GI. 2022. Long-term adaptation to galactose as a sole carbon source selects for mutations in nutrient signaling pathways. bioRxiv.

Papers & Perspectives

Vignogna RC, Allocca M, Monticelli M, Norris JW, Steet R, Andreotti G, Perlstein EO, Lang GI. 2022. Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease. Elife. Oct 10;11:e79346. doi: 10.7554/eLife.79346 pdf | publisher website

Aggeli D, Marad DA, Liu X, Buskirk SW, Levy SF, Lang GI. 2022. Overdominant and partially dominant mutations drive short-term adaptation in diploid yeast. Genetics. May 31;221(2):iyac061. doi: 10.1093/genetics/iyac061. pdf | publisher website

Fisher KJ, Vignogna RC, Lang GI. 2021. Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci. Genome Biol Evol. Aug 3;13(8):evab181. doi: 10.1093/gbe/evab181. pdf | publisher website

Vignogna RC, Buskirk SW, Lang GI. 2021. Exploring a local genetic interaction network using evolutionary replay experiments. Mol Biol Evol. Mar 22:msab087. doi: 10.1093/molbev/msab087. pdf | publisher website

Buskirk SW, Rokes AB, Lang GI. 2020. Adaptive evolution of nontransitive fitness in yeast. Elife. Dec 29;9:e62238. doi: 10.7554/eLife.62238. pdf | publisher website

McCandlish DM, Lang GI. 2020. Evolution of Epistasis: Small Populations Go Their Separate Ways. J Mol Evol. May 20;. doi: 10.1007/s00239-020-09950-4. pdf | publisher website

Lang GI, Rice AM. 2019. Evolution unscathed: Darwin Devolves argues on weak reasoning that unguided evolution is a destructive force, incapable of innovation. Evolution. March 13 doi: 10.1111/evo.13710. pdf | publisher website

Song G, Lee J, Kim J, Kang S, Lee H, Kwon D, Lee D, Lang GI, Cherry JM, Kim J. 2019. Integrative Meta-Assembly Pipeline (IMAP): Chromosome-level genome assembler combining multiple de novo assemblies. PLoS ONE. Aug 27;14(8):e0221858. doi: 10.1371/journal.pone.0221858. pdf | publisher website

Fisher KJ, Kryazhimskiy S, Lang GI. 2019. Detecting genetic interactions using parallel evolution in experimental populations. Philos Trans R Soc Lond B Biol Sci. Jul 22;374(1777):20180237. doi: 10.1098/rstb.2018.0237. pdf | publisher website

Fisher KJ, Buskirk SW, Vignogna RC, Marad DM, Lang GI. 2018. Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae. PLoS Genetics. May 25;14(5):e1007396. doi: 10.1371/journal.pgen.1007396. pdf | publisher website

Marad DM, Buskirk SW, Lang GI. 2018. Altered access to beneficial mutations slows adaptation and biases fixed mutations in diploids. Nature Ecology & Evolution. May;2(5):882-889. doi: 10.1038/s41559-018-0503-9. Epub 2018 Mar 26. pdf | publisher website

Lang GI. 2018. Measuring mutation rates using the Luria-Delbrück fluctuation assay. Methods Mol Biol. 1672:21-31. Epub 2017 Oct 17. pdf | publisher website

Buskirk SW, Peace RE, Lang GI. 2017. Hitchhiking and epistasis give rise to cohort dynamics in adapting populations. PNAS. Jul 18. pii: 201702314. pdf | journal website

Fisher KJ and Lang GI. 2016. Invited Review, Experimental evolution in fungi: An untapped resource. Fungal Genetics and Biology. Sep;94:88-94. Epub Jun 30. pdf | journal website

Frenkel EM, McDonald MJ, Van Dyken JD, Kosheleva K, Lang GI, and Desai MM. 2015. Crowded growth leads to the spontaneous evolution of semistable coexistence in laboratory yeast populations. PNAS. Sep 8;112(36):11306-11. Epub 2015 Aug 3. pdf | journal website

Lang GI and Desai MM. 2014. The spectrum of adaptive mutations in experimental evolution. Genomics. Dec;104(6 Pt A):412-6. Epub 2014 Sep 28. pdf | journal website

Lang GI, Rice DP, Hickman MJ, Sodergren E, Weinstock GM, Botstein D, and Desai MM,. 2013. Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations. Nature. Aug 29;500(7464):571-4. Epub 2013 Jul 21. pdf | journal website

Lang GI, Parsons L, and Gammie A. 2013. Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast. G3. Sep 4;3(9):1453-65. pdf | journal website

Lang GI, Botstein D, and Desai MM. 2011. Genetic variation and the fate of beneficial mutations in asexual populations. Genetics. Jul;188(3):647-61. Epub 2011 May 5. pdf | journal website

Lang GI, and Murray AW. 2011. Mutation rates across budding yeast Chromosome VI are correlated with replication timing. Genome Biology and Evolution. 3:799-811. Epub 2011 Jun 10. pdf | journal website

Lang GI, and Botstein D. 2011. A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast. PLoS ONE. Sep 22; 10.1371/journal.pone.0025290. pdf | journal website

Lang GI, Murray AW, and Botstein D. 2009. The cost of gene expression underlies a fitness trade-off in yeast. PNAS. Apr 7;106(14):5755-60. Epub 2009 Mar 19. pdf | journal website

Lang GI, and Murray AW. 2008. Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae. Genetics. Jan;178(1):67-82. pdf | journal website

Hepfer CE, Arnold-Croop S, Fogell H, Steudel KG, Moon M, Roff A, Zaikoski S, Rickman A, Komsisky K,Harbaugh DL, Lang GI, and Keil RL. 2005. DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae. Mol Genet Genomics. Dec;274(5):528-38. pdf | journal website